A Novel Shiga Toxin 1a-Converting Bacteriophage of Shigella sonnei With Close Relationship to Shiga Toxin 2-Converting Pages of Escherichia coli
نویسندگان
چکیده
In recent studies, strains of non-dysenteriae 1 Shigella (NDS) expressing Shiga toxin have been reported. In this study, we report a novel stx1a-converting bacteriophage of Shigella sonnei associated with travel to Mexico. Phylogenetic comparison between this and other stx-converting phages suggests that toxigenic NDS strains have arisen through separate horizontal transfer events from toxigenic Escherichia coli.
منابع مشابه
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References 1. Schmidt H. Shiga-toxin-converting bacteriophages. Res Microbiol. 2001;152:687–95. http://dx.doi.org/10.1016/ S0923-2508(01)01249-9 2. Melton-Celsa A, Mohawk K, Teel L, O’Brien A. Pathogenesis of Shiga-toxin producing Escherichia coli. Curr Top Microbiol Immunol. 2012;357:67–103. http://dx.doi.org/10.1007/82_2011_176 3. Manning SD, Motiwala AS, Springman AC, Qi W, Lacher DW, Ouelle...
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